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Heart Attack Risk after Heart Surgery

Bayer Suspends Trasylol Sales November 5, 2007

Benefits of Retaining Anapol Schwartz

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FDA Gets Trasylol Off the Market

BART Study Enrollment Ceases due to problems with Trasylol Safety.

Trasylol Wrongful Death Complaint

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Trasylol: Increased risks of heart attacks and strokes

Trasylol is a controversial antifibrinolytic agent used to minimize bleeding during heart surgery.

Studies have shown that there is an increased risk of heart attacks from Trasylol and an increased risk of stroke from Trasylol.

A recent study was conducted to determine whether Trasylol was better than either the generic tranexamic acid or aminocaproic acid. In this study, patients who were administered Trasylol had a higher rate of death than the other two agents. Because of the increased risk of heart attacks from Trasylol – this important study or trial which was reported in the New England Journal of Medicine ended earlier than planned.

In clinical trials, when compared to a placebo, Trasylol and the two other acid agents proved to be more effective in reducing the need for blood transfusion.  As for costs, the prices vary wildly. With Bayer’s Trasylol, a four-hour heart procedure costs $1,400 while the aminocaproic acid costs a mere $4.

You have to wonder if all things are equal: Why would a hospital opt to pay $1,400 instead of $4 and pass the savings along to the patient’s healthcare provider or directly to the hospital?

There is a concern that Trasylol has increased the risk of heart attacks and have increased the risk for strokes as well as kidney failure and short and long term mortality.

The controlled study was called BART - Blood Conservation Using Antifibrinolytics in a Randomized Trial (BART). The study was approved by the research ethics committee at each participating center. Written informed consent was obtained from all patients. None of the pharmaceutical companies making the study drugs contributed medications or financial support nor in the designing the study. All the patients underwent high-risk cardiac surgical procedures and were randomly chosen as to who received the Trasylol and the other two agents.

Causes of death were grouped post hoc as heart-related or non-heart-related. Cardiac causes consisted of congestive heart failure, shock, myocardial infarction, and right ventricular failure. Non-heart-related causes included hemorrhage, stroke, sepsis or multi-organ failure, and other or unknown causes.

A total of 108 of 2,331 patients died within 30 days after study randomization. The 30-day rate of death from any cause was 6 percent in the Trasylol group; as compared with 3.9 percent in the tranexamic acid group; and 4.0 percent in the aminocaproic acid group.

The study was terminated on October 2007 on the recommendation of the independent data

and safety committee who advised termination because of a strong trend toward higher mortality in the Trasylol group than in the other two groups.

Have you lost a family member because of Trasylol being administered during heart surgery? Has a family member experienced a Trasylol heart attack or Trasylol stroke?  You and your family could be eligible for an individual Trasylol lawsuit or class action Trasylol lawsuit. Find out if you qualify. Please answer a few questions and let’s determine what your legal options are.

Do you have a Trasylol/Aprotinin Lawsuit? Do you need a Trasylol/aprotinin lawyer to fight for you? Do you have an unsafe aprotinin lawsuit? Isn’t it about time to consider the options?

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TRASYLOL LAWSUIT INFORMATION

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Date of surgery:	MM January February March April May June July August September October November December DD 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 YYYY 2009 2008 2007 2006 2005 2004 2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 1993 1992 1991 1990 1989 1988 1987 1986 1985 1984 1983 1982 1981 1980 1979 1978 1977 1976 1975 1974 1973 1972 1971 1970 1969 1968 1967 1966 1965 1964 1963 1962 1961 1960 1959 1958 1957 1956 1955 1954 1953 1952 1951 1950 1949 1948 1947 1946 1945 1944 1943 1942 1941 1940 1939 1938 1937 1936 1935 1934 1933 1932 1931 1930 1929 1928 1927 1926 1925 1924 1923 1922 1921 1920 1919 1918 1917 1916 1915 1914 1913 1912 1911 1910 1909 1908 1907 1906 1905 1904 1903 1902
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Kidney failure Stroke Heart attack Heart failure Encephalopathy/brain disease Death
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