Researchers at UIC are studying the role that genetics play in the response to two different ADHD medications on Chidlren

Biological Responses to ADHD Medications

Researchers at UIC are studying the role that genetics play in the response to two different ADHD medications. Attention Deficit and Hyperactivity Disorder, more commonly known as ADHD, has been studied extensively and new medications have been developed to help combat this prevalent mental illness; however, not many studies have been conducted regarding genetics and individual response to these medications.

The experimental design study includes the evaluation of 160 children and adolescents between the ages of 7 and 17. The subjects will receive IQ, achievement, blood, and physical exams, along with an initial psychiatric evaluation and an electrocardiogram test to measure each subject's eligibility to become a participant. Volunteers will be treated with atomoxetine (non-stimulant medication), melthylphenidate (stimulant medication), and a placebo in a blinded-dose sequence to determine the effectiveness of the medications. Researchers will then measure any ADHD symptoms and look for an increase in social and attention skills in the participants while taking the medications.

Two of the most common stimulant based medications used in the treatment of ADHD, Adderall and Concerta, and the most common non-stimulant based medication prescribed, Strattera, work by increasing the strength and effectiveness of chemical signaling.