A new study released January 3, 2007 revealed that Permax and Dostinex, – two Parkinson’s disease treatment drugs, cause the same kind of heart valve damage and heart damage that led to the withdrawal of the dangerous diet drug combination, fen-phen. The study was published in the New England Journal of Medicine.
Permax is the brand name for pergolide, a medicine used to treat tremors and other symptoms of Parkinson's disease. Permax is also used by people who suffer from Restless Leg Syndrome (RLS).
The study confirms that patients taking the drugs pergolide, developed by Eli Lilly & Co. and sold under the brand name Permax; and cabergoline, developed by Pfizer Inc. and sold under the brand Dostinex, had a sharply higher risk of heart valve damage than those taking other therapies.
Have you or a loved one suffered heart valve damage caused by taking Permax or Dostinex? Do you need a Permax injury lawyer?
Two studies analyzed the records of 11,417 patients in Britain and tested 245 patients in Italy. These studies reinforce the results of previous, smaller studies that demonstrate that these types of drugs activate a cellular receptor known as 5-HT2b that can cause damage to the heart valve. A damaged heart valve is a serious condition that can lead to heart failure and sudden death.
The British study revealed that patients taking Permax (pergolide) were 7.1 times more likely to develop heart valve damage than those who took other treatments. Patients taking the highest doses Permax had a 37 times greater risk.
The study conducted in Italy tested 245 people, 155 people had Parkinson's disease. Of the Parkinson’s population, one group received Permax (pergolide), one group received Dostinex (cabergoline), and one group received an alternative Parkinson's treatment. The non-diseased control group received nothing.
The results showed that 23.4 percent of patients taking Permax and 28.6 percent of patients taking Dostinex suffered heart damage, compared with just 5.6 percent in the control group which points to huge risks of heart damage.
More than a half million people have taken Permax. Are you one of them? Are you suffering from heart damage or heart valve damage after being prescribed Permax? Now is the time to talk to a Permax lawyer about your possible Permax lawsuit.