Bisphosphonates (Fosamax) are the most common class of drugs used for the treatment of osteoporosis. Bisphosphonates have proven to be effective for fracture reduction but the incidence of micro-cracks - small cracks in the skeleton - has been shown to increase with bisphosphonates treatment. This leads to concerns regarding the potential long-term adverse effects of these alleged osteoporosis prevention drugs. However, the study demonstrated that with long-term use of bisphosphonates (Fosamax) the skeletal micro-cracks did not increase with long term usage.The new research was presented at the 28th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR). (Science Daily)