Actos is considered a TZD or in a class of drugs called thiazolidinediones.
Peroxisome proliferator-activated receptors (PPARs) have emerged as important drug targets for diabetes. Drugs that activate PPARγ, such as the thiazolidinediones (TZDs), are widely used in the treatment of Type 2 diabetes mellitus. The effects of TZDs on cancer risk in humans needs to be resolved as these drugs are prescribed for long periods of time in patients with diabetes.
This study was published by the University of Vermont in 2007.
Method: 1,003 people were interviewed at home at the time of enrollment in the Vermont Diabetes Information System, a clinical decision support program. Patients self-reported their personal and clinical characteristics, including any history of malignancy. Laboratory data were obtained directly from the clinical laboratory and current medications were obtained by direct observation of medication containers. A cross-sectional analysis of the interviewed subjects was performed to assess a possible association between cancer diagnosis and the use of TZDs.
Contact Anapol Schwartz to find out what your legal rights are.
Have you been taking Actos for type 2 diabetes for more than a year? If the answer is yes and you have been diagnosed with cancer, particularly bladder cancer – please contact Anapol Schwartz about a possible unsafe drug lawsuit.
Results: In a multivariate logistic regression model, a diagnosis of cancer was significantly associated with TZD use, even after correcting for potential confounders including other oral anti-diabetic agents, age, glycosylated hemoglobin A1C, body mass index, cigarette smoking, high comorbidity, and number of prescription medications. This association was particularly strong among patients using rosiglitazone and among women.
Conclusion: These data suggest an association between TZD use and cancer in patients with diabetes. Further studies are required to determine if this association is causal.
Source: BioMed Central
Have you been taking Actos for type 2 diabetes for more than a year?
If the answer is yes and you have been diagnosed with cancer, particularly bladder cancer – please contact Anapol Schwartz about a possible unsafe drug lawsuit. Medications for type 2 diabetes should not be causing another life threatening medical condition.